To date, the mechanism underlying its release in cells is not fully understood.
A recent work led by MD/PhD student Inabr Shlomovitz and Dr. Motti Gerlic demonstrate that necroptosis, a form of cell death, triggers the release of IL-33 in its bioactive form. Inhibition of necroptosis in an Aspergillus allergic asthma model results in reduced inflammation, providing in vivo evidence that necroptosis contributes to IL-33-associated inflammatory disease.
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