New system for detecting Parkinson’s early

Written on |

New method tracks early stages of protein aggregation involved in Parkinson’s

Parkinson’s disease is a debilitating neurodegenerative disease, affecting everything from speech, posture and gait to digestion, sleep, impulse control and cognition. Therapies exist that alleviate some symptoms of the disease, but there is still no cure for Parkinson’s, which affects close to one million Americans and 10 million people worldwide.

A new Tel Aviv University study unveils a novel method for detecting the aggregation of the protein alpha-synuclein, a hallmark of Parkinson’s disease. With this knowledge, caregivers could introduce treatment that has the potential to significantly delay disease progression.

By the time a patient is diagnosed with Parkinson’s disease, 50 percent to 80 percent of the dopaminergic cells in the part of the brain called substania nigra are already dead, possibly due to development of toxicity as result of alpha-synuclein aggregation. “We have developed a new method for tracking early stages of aggregation of alpha-synuclein using super-resolution microscopy and advanced analysis,” says Prof. Uri Ashery, co-author of the study and head of TAU’s Sagol School of Neuroscience and TAU’s George S. Wise Faculty of Life Sciences. The research was published in Acta Neuropathologica on May 31.

“Together with our collaborators at Cambridge University, who developed a special mouse model for Parkinson’s disease, we were able to detect different stages of the aggregation of this protein,” Prof. Ashery explains. “We correlated the aggregation with the deteriorating loss of neuronal activity and deficits in the behavior of the mice.”

A big step towards early detection

“This is extremely important because we can now detect early stages of alpha-synuclein aggregation and monitor the effects of drugs on this aggregation,” says Dr. Dana Bar-On of the Sagol School of Neuroscience, a co-author of the study. “We hope that this research can be implemented for use in the early diagnosis of Parkinson’s in patients. We’re currently working to implement the methods in a minimally invasive manner with Parkinson’s patients.”

The researchers, in collaboration with the Max Planck Institute in Gottingen and Ludwig-Maximilians-Universität München, were able to illustrate the effect of a specific drug, anle138b, on this protein aggregation and correlated these results with the normalization of the Parkinson’s phenotype in the mice, according to Prof. Ashery. “This is a significant step forward in the world of Parkinson’s research,” he says.

The researchers are planning to expand their research to family members of Parkinson’s disease patients. “By detecting aggregates using minimally invasive methods in relatives of Parkinson’s disease patients, we can provide early detection and intervention and the opportunity to track and treat the disease before symptoms are even detected,” Prof. Ashery concludes.

Related posts

Want to Live Longer? Find Out if You Snore

May 15, 2022

TAU Researchers Invent Healthy Weapon Against Covid

April 14, 2022

Is the Vaccine Safe? Consult the Smart Sensor!

April 11, 2022

TAU Nanodrug Enables 2-in-1 Attack on Cancer

April 5, 2022

Minor Head Injury Leads to Chronic Post-Concussion Syndrome in 1 of 4 Children

March 28, 2022

Inventive Study to Develop Biological Solutions for Agriculture

March 27, 2022

TAU Technology Could Prevent Repeat Heart Valve Surgery

March 24, 2022

Israeli Breakthrough in Treating PTSD

February 22, 2022

Can Higher Temperatures Accelerate the Rate of Evolution?

February 16, 2022

Discovery May Enable Early Diagnosis of Alzheimer’s

February 15, 2022

TAU Breakthrough Offers New Hope to Help People With Paralysis Walk Again

February 3, 2022

Ketogenic Diet Likely to Reduce Damage from Traumatic Brain Injuries

January 25, 2022

Reading Tea Leaves

January 25, 2022

Viruses and Game Theory

January 24, 2022

What’s The Link Between Electrical Voltage and Brain Adaptability?

January 23, 2022

As Pandemic Persists, TAU Forges Ahead with COVID-19 Research on All Fronts

December 30, 2021

Rising Temperatures Fuel Increase in Violence: TAU Study

December 26, 2021

Medicinal Cannabis Oil Effective for Treating Autism

December 22, 2021

Parent Smartphone Use Could Harm Child Development

December 19, 2021

Breakthrough TAU Discovery Key to Reversing ALS

December 16, 2021

Experimental Drug Displays Effectiveness in Treating Symptoms of Autism and Alzheimer’s Disease

December 15, 2021

Seaweed – A Promising Defense Against Covid-19

December 15, 2021

New Ethical Code for World Research of Ancient DNA

December 14, 2021

Saving Lives with Artificial Intelligence

December 9, 2021

TAU Experts on Omicron: “Don’t Panic”

December 7, 2021

Tired of The Lies?

November 23, 2021

Britain and Israel Team Up on Challenge of Healthy Ageing

November 10, 2021

TAU Researchers Identify COVID Proteins that Cause Strokes and Heart Attacks

November 8, 2021

Can’t Multitask Anymore?

October 6, 2021

Why Do We Squabble Over The AC?

October 5, 2021

The Immune System’s Double Agents

October 5, 2021

Help A Friend Out?

September 30, 2021

Using ‘Good’ Bacteria to Fight ‘Bad’ Bacteria

September 29, 2021

Recruiting ‘Fighting Cells’ to Destroy Tumors

September 14, 2021

TAU Team Reverses Early Signs of Alzheimer’s

September 10, 2021

Nicotine Testing of Children Curbs Parents’ Smoking

September 5, 2021

Want to Fall in Love? Step Outside in The Sun

August 31, 2021

The Silent Prophets

August 31, 2021

First 3D-bioprinting of entire active tumor

August 18, 2021

New Warning Sign for Breast Cancer

August 6, 2021

COVID-19 Immunity Varies Among Genders and Age Groups

July 26, 2021

Tel Aviv Bats Have More Fun

July 22, 2021

New study found differences between women and men in the level of COVID-19 antibodies

July 15, 2021

A world first: Technology that restores the sense of touch in nerves damaged as a result of amputation or injury

July 15, 2021

TAU Medical Student to Swim for Israel at Summer Olympics

July 15, 2021

New nanotech from TAU produces “healthy” electric current from the human body itself

July 9, 2021

Introducing the world’s thinnest technology – only two atoms thick

July 2, 2021

Want to Live a Long Life? Consider Investing in Your Marriage.

July 2, 2021

A world first: Targeted delivery of therapeutic RNAs only to cancer cells, with no harm caused to healthy cells

June 30, 2021

Combating Antibiotic Resistance

June 22, 2021

Pursuing the Unknown

Copyright ©  Tel Aviv University Trust. All rights reserved.
Registered charity number 314179.